A new study reports that the recurrent CREBBP Y1503C mutation promotes diffuse large B-cell lymphoma growth and CD8+ T-cell ...

中国医学科学院北京协和医学院、呼吸和共病全国重点实验室杨信怡团队与英国牛津大学 Penny A. Handford 团队合作，在中国工程院院刊《Engineering》发表了题为 “The Notch Signaling Pathway: Mechanistic Insights in Health and Disease” 的综述文章，深入探讨了 Notch 信号通路在 ...

Notch signalling is a conserved cell‐to‐cell communication pathway that directs the fate of multipotent precursors and stem cells. Engagement of Notch receptors by membrane-bound ligands triggers ...

In the Drosophila ovary, Notch activation upregulates the E2 enzyme Ubc10, which teams with the E3 ligases Ari-1 and Cul3 to ...

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key ...

Ten years of substantial work by Université de Montréal immunologist Nathalie Labrecque's team at the Montreal Clinical Research Institute (IRCM) and the Maisonneuve-Rosemont Hospital Research Center ...

Breast cancer (BC) remains one of the most challenging cancers to treat, primarily due to its heterogeneity and propensity for metastasis. The Notch signaling pathway is integral to various cellular ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Jan Kitajewski, PhD, explains how Notch inhibitors may sustain specialized tumor blood vessels that deliver immune cells and ...

Signal transduction The cellular process that converts a signal, such as a hormone, growth factor, neurotransmitter, cytokine, mechanical force, or environmental cue, into biochemical changes inside ...